Latest Research
Simvastatin restores spatial memory in β‑amyloid‑injected mice by reducing HDAC2 and increasing BDNF
Simvastatin reversed β‑amyloid‑induced cognitive deficits in mice, normalizing HDAC2, histone H4 acetylation, and BDNF levels
Anti-PD-L2 therapy boosts insulin sensitivity and grip strength by lowering senescent cell load in aged mice
Anti-PD-L2 treatment increased insulin sensitivity and grip strength in aged wild-type mice.
GLP-1 Receptor Agonists Lower Glaucoma Risk but May Pose Uncertain Optic Neuropathy Risk
GLP‑1 receptor agonists are linked to a decreased incidence of age‑related glaucoma, while evidence for severe non‑arteritic anterior ischemic optic neuropathy remains inconclusive.
Probiotic Bifidobacterium pseudocatenulatum converts hesperidin to hesperetin, activating CISD2 and reversing age‑related metabolic decline in mice
Six‑month probiotic‑derived hesperetin treatment reduced body weight and adiposity while improving glucose tolerance, insulin sensitivity, lean mass, and muscle strength in aging mice
EPVS Challenge shows top deep‑learning models reach Dice >0.80 on known sites but lose >20% accuracy on unseen Shanghai cohort
The MedNeXt dual 2D/3D model achieved the highest Dice score, yet its performance declined sharply on the previously unseen Shanghai dataset.
Senolytic BCL2 and IAP inhibition amplifies docetaxel-induced anti‑tumor immunity and blocks metastasis in prostate cancer
Senolytic BCL2/IAP inhibition after docetaxel treatment reduced tumor growth and metastasis in prostate cancer mouse models.
Mild stress triggers hormetic responses that extend Drosophila lifespan and increase survival after heart attack in angina patients
Mild stress was associated with increased survival after heart attack in angina patients.
Intestinimonas remains elevated in aged SAMP8 mice and links to opposite CD4⁺/CD8⁺ T‑cell ratio shifts in brain versus spleen
Aged SAMP8 mice retain higher Intestinimonas levels and show an increased brain CD4⁺/CD8⁺ T‑cell ratio with more pro‑inflammatory CD4⁺ T cells compared to SAMR1 controls.
Growth Hormone Adjunct Therapy Boosts Oocyte Yield and Live‑Birth Rates in Assisted Reproductive Technology
Adjunct GH therapy in ART is linked to increased oocyte yield, improved embryo quality, and higher pregnancy and live‑birth rates.
GLP-1 receptor agonists cut all-cause mortality by 19% in obese patients and slow epigenetic aging clocks
GLP-1 RAs reduced all-cause mortality by 19% (HR 0.81) in obese non-diabetic patients and decelerated DNA methylation aging clocks over 32 weeks of semaglutide therapy.
Molecular hydrogen delivers dual antioxidant and radioprotective actions that may support longevity
Molecular hydrogen reduces oxidative stress and mitigates radiation‑induced cellular damage.
Comprehensive review maps multi-level mechanisms of bone aging and highlights senolytics as emerging therapy
The review identifies senolytics as a promising intervention to counteract bone aging.
Thymoquinone and Intermittent Fasting Synergistically Reduce Oxidative Stress, p‑Tau, and Amyloid β While Enhancing Neurogenesis and Autophagy in an Aluminum‑Induced Rat Model of Alzheimer’s Disease
Combined thymoquinone (50 mg/kg/day) and 14‑hour intermittent fasting lowered MDA, p‑Tau, amyloid β, Bax, and CD68 levels while raising SOD, LC3B‑II, and nestin‑positive cell counts in AlCl₃‑induced AD rats
Fasting activates AMPK and sirtuin pathways to remodel the epigenome, enhancing autophagy and stem cell function
Fasting activates AMPK and sirtuin signaling, leading to epigenomic remodeling that supports autophagy and stem cell maintenance.
Protocatechuic, Gallic, and Vanillic Acids Enhance Mitochondrial Function and Activate Hormetic Pathways in C. elegans
All three phenolic acids increased mitochondrial respiration and up‑regulated SKN‑1/Nrf2‑mediated hormetic signaling in C. elegans.
Anti-OPG Antibody Therapy Attenuates Pulmonary Arterial Hypertension Severity in Rodent Models
Therapeutic anti‑OPG antibody treatment reduced disease severity in multiple rodent PAH models.
Acute exercise and fasting increase brain mitophagy markers
Acute bouts of exercise and fasting raise mitophagy-related protein levels in brain tissue.