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PARTICIPATE Framework Proposed to Reduce Excess Mortality and Morbidity among Older Adults in Humanitarian Crises
The paper proposes the PARTICIPATE framework, which is intended to reduce excess mortality, morbidity, disability, exclusion, and care dependence among older people in humanitarian crises.
Human studies reveal limited activation of autophagic flux by fasting and calorie restriction, contrasting robust effects in animal models
Human nutritional interventions (prolonged fasting, intermittent fasting, calorie restriction, macronutrient changes) have shown little or no increase in autophagic flux
Survey Reveals Lifetime Cognitive Enhancer Use Prevalence Among Syrian University Students
The cross‑sectional survey found that a proportion of Syrian university students reported lifetime use of cognitive enhancers (no comparative increase or decrease reported).
Intravenous mitochondria‑rich cytochalasomes cut infarct size by 52% in mouse heart ischemia/reperfusion
A single IV injection of mitochondria‑rich cytochalasomes reduced myocardial infarct size by 52% and preserved cardiac function for up to 28 days in a murine I/R model.
5.4% of centenarians harbor neutralizing type I interferon autoantibodies, indicating prevalence plateaus at extreme age
5.4% of centenarians have neutralizing IFN‑I autoantibodies, showing prevalence levels off compared with individuals aged ≥80 years.
Combined urolithin A and STING inhibitor C176 synergistically reduces liver injury, inflammation, and fibrosis in a mouse steatohepatitis model
In a high‑fat diet/streptozotocin mouse model of steatohepatitis, the combination of urolithin A and C176 produced greater reductions in ALT/AST, lipid accumulation, cGAS‑STING signaling, and fibrosis than either agent alone.
Nutritional cues modulate chaperone-mediated autophagy, altering tumor metabolism and therapeutic response
Nutritional signals such as caloric restriction and fasting regulate CMA, which in turn impacts cancer cell metabolic adaptation and survival
Epitalon upregulates telomere‑maintenance pathways and lowers oxidative‑stress markers but lacks proven clinical efficacy
Epitalon increases telomere‑maintenance activity and reduces oxidative‑stress biomarkers in preclinical models, with no demonstrated therapeutic benefit in human trials.
Electroactive BaTiO3‑GelMA Nerve Conduit Restores Myelination and Functional Recovery in Peripheral Nerve Gaps
The engineered bilayer conduit markedly enhanced nerve fiber regeneration, myelin maturation, and target muscle function, reaching outcomes similar to autologous grafts.
Body temperature, not hexosamine pathway, controls global protein O-GlcNAcylation across mice, flies, fish and cells
Reduced body temperature lowers global protein O-GlcNAc levels independent of UDP‑GlcNAc availability
Swiss Osteoporosis Guidelines Prioritize Anabolic‑First Therapy for Imminent and Very High Fracture Risk
The updated Swiss guidelines recommend anabolic‑first treatment for patients at imminent or very high fracture risk to achieve the fastest hip BMD gains.
fMRI reveals modality-switching bows and a balanced audiovisual axis during natural movie viewing
Large-scale fMRI identified two cortical modality-switching bows and an arrow-like region that jointly encode auditory and visual information in naturalistic comprehension.
DOTMA/DNA 10:1 DP20CQ niosomes achieve superior transgene expression in senescent umbilical‑cord MSCs versus Lipofectamine
DP20CQ niosomes at a DOTMA/DNA ratio of 10:1 produced higher transgene expression in Palbociclib‑induced senescent UC‑MSCs than Lipofectamine without reducing cell viability
Ayurvedic Medhya Rasayanas Upregulate BDNF and Promote Hippocampal Neurogenesis in Models of Cognitive Decline
Ayurvedic herbs such as Bacopa monnieri, Centella asiatica, and Withania somnifera increase BDNF expression and stimulate hippocampal neurogenesis, supporting cognitive resilience.
Ultrasound‑Activated Piezoelectric Hydrogel Boosts Mitophagy and Protects Cartilage in a Mouse Osteoarthritis Model
Ultrasound‑activated GM@KP‑ABs increased mitophagic activity and reduced cartilage degeneration in a DMM‑induced mouse OA model.
Chemogenetic modulation of VIP+ neurons in medial prefrontal cortex reduces associative fear learning in mice
Sustained chemogenetic activation or inhibition of VIP+ neurons in the mPFC markedly decreased associative fear learning without affecting anxiety or social behaviors.
Disrupting the Left Inferior Frontal Gyrus Increases Semantic Interference in Picture Naming, Especially for Previously Related Items
Cathodal tDCS over the LIFG slowed naming latencies for items initially presented in related contexts, indicating heightened semantic interference.