Protocols
Cutting-edge protocols and applied science
Latest Research
PARTICIPATE Framework Proposed to Reduce Excess Mortality and Morbidity among Older Adults in Humanitarian Crises
The paper proposes the PARTICIPATE framework, which is intended to reduce excess mortality, morbidity, disability, exclusion, and care dependence among older people in humanitarian crises.
Electroactive BaTiO3‑GelMA Nerve Conduit Restores Myelination and Functional Recovery in Peripheral Nerve Gaps
The engineered bilayer conduit markedly enhanced nerve fiber regeneration, myelin maturation, and target muscle function, reaching outcomes similar to autologous grafts.
Swiss Osteoporosis Guidelines Prioritize Anabolic‑First Therapy for Imminent and Very High Fracture Risk
The updated Swiss guidelines recommend anabolic‑first treatment for patients at imminent or very high fracture risk to achieve the fastest hip BMD gains.
DOTMA/DNA 10:1 DP20CQ niosomes achieve superior transgene expression in senescent umbilical‑cord MSCs versus Lipofectamine
DP20CQ niosomes at a DOTMA/DNA ratio of 10:1 produced higher transgene expression in Palbociclib‑induced senescent UC‑MSCs than Lipofectamine without reducing cell viability
Ultrasound‑Activated Piezoelectric Hydrogel Boosts Mitophagy and Protects Cartilage in a Mouse Osteoarthritis Model
Ultrasound‑activated GM@KP‑ABs increased mitophagic activity and reduced cartilage degeneration in a DMM‑induced mouse OA model.
Citicoline 1000 mg/day improves 90‑day MMSE, Barthel Index, and GOS‑E scores in mild‑to‑moderate TBI patients
Citicoline 1000 mg/day increased 90‑day MMSE, Barthel Index, and GOS‑E scores compared with placebo in mild‑to‑moderate traumatic brain injury.
Intermittent dasatinib plus quercetin therapy improves fibrosis stage and resolves MASH in a phase‑2 double‑blind RCT
In a double‑blind randomized trial, intermittent dasatinib 100 mg + quercetin 1000 mg achieved ≥1‑stage fibrosis improvement in 47% of fibrotic MASH patients versus 7% with placebo.
Senolytic BCL2 and IAP inhibition amplifies docetaxel-induced anti‑tumor immunity and blocks metastasis in prostate cancer
Senolytic BCL2/IAP inhibition after docetaxel treatment reduced tumor growth and metastasis in prostate cancer mouse models.
Thymoquinone and Intermittent Fasting Synergistically Reduce Oxidative Stress, p‑Tau, and Amyloid β While Enhancing Neurogenesis and Autophagy in an Aluminum‑Induced Rat Model of Alzheimer’s Disease
Combined thymoquinone (50 mg/kg/day) and 14‑hour intermittent fasting lowered MDA, p‑Tau, amyloid β, Bax, and CD68 levels while raising SOD, LC3B‑II, and nestin‑positive cell counts in AlCl₃‑induced AD rats
Bacopa‑enriched formulation improves memory and restores hippocampal LTP in rat model of vascular dementia
Oral BEF (50‑300 mg/kg for 7 days) dose‑dependently enhanced passive avoidance and Morris water maze performance and rescued hippocampal long‑term potentiation deficits in 2‑VO rats.
Bacopa Monnieri Reduces Neurodegenerative Biomarkers and Improves Cognitive Function
Bacopa monnieri supplementation decreased pro-inflammatory biomarkers and oxidative stress, and improved cognitive functions and emotional function.