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Disrupting the Left Inferior Frontal Gyrus Increases Semantic Interference in Picture Naming, Especially for Previously Related Items
Cathodal tDCS over the LIFG slowed naming latencies for items initially presented in related contexts, indicating heightened semantic interference.
Advanced maternal age markedly reduces blastocyst formation and live‑birth rates, linked to distinct age‑associated gene expression and metabolomic shifts in oocytes
Women of advanced age had significantly lower blastocyst formation, pregnancy, and live‑birth rates compared with younger women
Group-living rodents exhibit higher oxytocin and vasopressin puncta in auditory brainstem nuclei
Group-living rodent species have higher oxytocin and vasopressin immunoreactive puncta counts in the lateral superior olive and medial nucleus of the trapezoid body than monogamous and solitary species.
Blood transcriptomic profiling of 2,167 long‑lived individuals uncovers 8,271 age‑associated genes and links higher transcriptomic age to increased mortality
Transcriptomic age derived from blood RNA‑seq rises with chronological age and is strongly associated with higher mortality risk
CA2-3 volume predicts source memory while dentate gyrus volume predicts broader cognitive performance across the adult lifespan
In 163 cognitively healthy adults, larger CA2-3 volume was linked to better source memory and larger dentate gyrus volume was linked to both mnemonic and non‑mnemonic cognitive scores, with effects independent of age
Bacterial extracellular vesicles drive inflammation and insulin resistance in cardiometabolic disease
Bacterial extracellular vesicles increase systemic inflammation and decrease insulin sensitivity, contributing to cardiometabolic disease.
A single residue pinning hotspot drives tau fibril extension via a two-step dock-and-lock mechanism
Blocking the identified pinning hotspot shortens tau fibrils and disrupts templated aggregation
Citicoline 1000 mg/day improves 90‑day MMSE, Barthel Index, and GOS‑E scores in mild‑to‑moderate TBI patients
Citicoline 1000 mg/day increased 90‑day MMSE, Barthel Index, and GOS‑E scores compared with placebo in mild‑to‑moderate traumatic brain injury.
Cellular senescent-cell clearance prevents or partially reverses age‑related bone loss in preclinical models
Preclinical studies show that clearing senescent cells can prevent or partially reverse bone loss associated with aging.
pepR‑MS enables mapping of >34,000 protein‑RNA crosslinks at single‑amino‑acid resolution in breast cancer cells
pepR‑MS identified over 34,000 unique peptide‑RNA crosslinks in 589 proteins of breast cancer cells.
Intermittent dasatinib plus quercetin therapy improves fibrosis stage and resolves MASH in a phase‑2 double‑blind RCT
In a double‑blind randomized trial, intermittent dasatinib 100 mg + quercetin 1000 mg achieved ≥1‑stage fibrosis improvement in 47% of fibrotic MASH patients versus 7% with placebo.
Obesity Associated with Depleted Methanogenic Archaea and Enriched Caudoviricetes Bacteriophages Across Three Human Cohorts
Obese individuals show reduced gut abundance of methanogenic archaea (Methanobrevibacter smithii and M. millerae) and increased abundance of Caudoviricetes bacteriophages.
MgO amendment reduces Pb leaching to 0.02 mg/L and retains low metal leaching after 100‑year simulated aging
MgO lowered Pb leaching from 84.62 mg/L to 0.02 mg/L and kept Pb at ~0.07 mg/L after 100 years of accelerated aging, outperforming CaO and biochar
Association of Self‑Selected Moderate Low‑Carbohydrate Diet Adherence with Cardiometabolic Parameters in Adults With and Without Diabetes
The abstract reports that the study evaluated the association between moderate low‑carbohydrate diet adherence and cardiometabolic parameters, but specific outcome results are not provided.
Intrinsic timescale lengthens hierarchically from sensorimotor to association cortex during youth development
Intrinsic timescale increases in association cortex relative to sensorimotor cortex across ages 8‑22, stabilizing in adulthood
Imeglimin Reduces Muscle Atrophy in Metabolic Dysfunction-Associated Steatohepatitis Models
The study examined imeglimin's impact on MASH‑associated muscle atrophy, but the abstract does not report the outcome.
Simvastatin restores spatial memory in β‑amyloid‑injected mice by reducing HDAC2 and increasing BDNF
Simvastatin reversed β‑amyloid‑induced cognitive deficits in mice, normalizing HDAC2, histone H4 acetylation, and BDNF levels