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Comprehensive review maps multi-level mechanisms of bone aging and highlights senolytics as emerging therapy
The review identifies senolytics as a promising intervention to counteract bone aging.
Thymoquinone and Intermittent Fasting Synergistically Reduce Oxidative Stress, p‑Tau, and Amyloid β While Enhancing Neurogenesis and Autophagy in an Aluminum‑Induced Rat Model of Alzheimer’s Disease
Combined thymoquinone (50 mg/kg/day) and 14‑hour intermittent fasting lowered MDA, p‑Tau, amyloid β, Bax, and CD68 levels while raising SOD, LC3B‑II, and nestin‑positive cell counts in AlCl₃‑induced AD rats
Fasting activates AMPK and sirtuin pathways to remodel the epigenome, enhancing autophagy and stem cell function
Fasting activates AMPK and sirtuin signaling, leading to epigenomic remodeling that supports autophagy and stem cell maintenance.
Protocatechuic, Gallic, and Vanillic Acids Enhance Mitochondrial Function and Activate Hormetic Pathways in C. elegans
All three phenolic acids increased mitochondrial respiration and up‑regulated SKN‑1/Nrf2‑mediated hormetic signaling in C. elegans.
Anti-OPG Antibody Therapy Attenuates Pulmonary Arterial Hypertension Severity in Rodent Models
Therapeutic anti‑OPG antibody treatment reduced disease severity in multiple rodent PAH models.
Acute exercise and fasting increase brain mitophagy markers
Acute bouts of exercise and fasting raise mitophagy-related protein levels in brain tissue.
Haemoproteus macrovacuolatus-like parasites detected in captive Ruddy Shelduck and black‑necked swans reveal morphological divergence from classic description
Haemoproteus macrovacuolatus-like infection was identified in one female of each captive bird species, with 100% cytb gene sequence similarity but altered parasite morphology.
Impaired β5t Thymoproteasome and AIRE-Mediated Antigen Presentation Drive Autoimmunity: Review of Emerging Therapeutic Targets
Defects in thymic selection mechanisms, including reduced β5t thymoproteasome activity and diminished AIRE-driven tissue‑restricted antigen expression, are associated with increased risk of autoimmune disease.
Senomorphic agents suppress SASP by targeting NF-κB, mTOR, JAK/STAT and cGAS‑STING pathways
Senomorphic compounds reduce senescence‑associated secretory phenotype signaling without eliminating senescent cells.
Calorie restriction induces early IGF1R/PI3K suppression in short-lived Argopecten irradians and delayed FoxO activation in long-lived Argopecten purpuratus, linking to lifespan extension
Calorie restriction downregulated metabolic pathways in both scallop species, with early IGF1R/PI3K/INSR suppression in A. irradians and delayed FoxO activation in A. purpuratus.
Human Milk Oligosaccharides Enhance Hippocampal Plasticity and Anti‑Inflammatory Microglia via the Gut‑Brain Immune Axis
Human milk oligosaccharides promote beneficial gut microbiota, increase hippocampal plasticity, and drive anti‑inflammatory microglia polarization.
Multi‑modal brain aging clocks reveal regional heterogeneity and cellular‑level aging mechanisms
Brain aging clocks detect accelerated brain aging linked to cellular senescence and can predict neurodegenerative disease risk.
Bacopa‑enriched formulation improves memory and restores hippocampal LTP in rat model of vascular dementia
Oral BEF (50‑300 mg/kg for 7 days) dose‑dependently enhanced passive avoidance and Morris water maze performance and rescued hippocampal long‑term potentiation deficits in 2‑VO rats.
CREM acts as a checkpoint that suppresses NK cell cytotoxicity and cytokine release in CAR‑NK therapy
CREM activation reduces NK cell cytotoxicity and cytokine production in CAR‑NK models.
Delayed clearance of p16Ink4a‑positive senescent cells improves frailty, cognition, blood‑brain barrier integrity and extends median survival in irradiated mice
Clearing p16Ink4a‑positive cells 4 months after whole‑body irradiation reduced frailty, improved neuromuscular and cognitive function, restored blood‑brain barrier integrity, improved hepatic metabolism, and increased median survival in mice
RobustCell framework shows targeted attacks degrade clustering and annotation accuracy in single‑cell and spatial transcriptomics, while defense policies restore performance
Targeted attacks significantly reduced clustering and cell‑type annotation accuracy of transcriptomic analysis methods, and defense strategies mitigated these performance drops
Investigation of Methylophiopogonanone A's antioxidant and anti‑inflammatory effects in myocardial ischemia‑reperfusion injury
Methylophiopogonanone A shows antioxidant and anti‑inflammatory activities, but its impact on myocardial ischemia‑reperfusion injury remains undefined