Science
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Latest Research
Bacterial extracellular vesicles drive inflammation and insulin resistance in cardiometabolic disease
Bacterial extracellular vesicles increase systemic inflammation and decrease insulin sensitivity, contributing to cardiometabolic disease.
A single residue pinning hotspot drives tau fibril extension via a two-step dock-and-lock mechanism
Blocking the identified pinning hotspot shortens tau fibrils and disrupts templated aggregation
Cellular senescent-cell clearance prevents or partially reverses age‑related bone loss in preclinical models
Preclinical studies show that clearing senescent cells can prevent or partially reverse bone loss associated with aging.
pepR‑MS enables mapping of >34,000 protein‑RNA crosslinks at single‑amino‑acid resolution in breast cancer cells
pepR‑MS identified over 34,000 unique peptide‑RNA crosslinks in 589 proteins of breast cancer cells.
Obesity Associated with Depleted Methanogenic Archaea and Enriched Caudoviricetes Bacteriophages Across Three Human Cohorts
Obese individuals show reduced gut abundance of methanogenic archaea (Methanobrevibacter smithii and M. millerae) and increased abundance of Caudoviricetes bacteriophages.
Association of Self‑Selected Moderate Low‑Carbohydrate Diet Adherence with Cardiometabolic Parameters in Adults With and Without Diabetes
The abstract reports that the study evaluated the association between moderate low‑carbohydrate diet adherence and cardiometabolic parameters, but specific outcome results are not provided.
Intrinsic timescale lengthens hierarchically from sensorimotor to association cortex during youth development
Intrinsic timescale increases in association cortex relative to sensorimotor cortex across ages 8‑22, stabilizing in adulthood
Imeglimin Reduces Muscle Atrophy in Metabolic Dysfunction-Associated Steatohepatitis Models
The study examined imeglimin's impact on MASH‑associated muscle atrophy, but the abstract does not report the outcome.
Simvastatin restores spatial memory in β‑amyloid‑injected mice by reducing HDAC2 and increasing BDNF
Simvastatin reversed β‑amyloid‑induced cognitive deficits in mice, normalizing HDAC2, histone H4 acetylation, and BDNF levels
Anti-PD-L2 therapy boosts insulin sensitivity and grip strength by lowering senescent cell load in aged mice
Anti-PD-L2 treatment increased insulin sensitivity and grip strength in aged wild-type mice.
GLP-1 Receptor Agonists Lower Glaucoma Risk but May Pose Uncertain Optic Neuropathy Risk
GLP‑1 receptor agonists are linked to a decreased incidence of age‑related glaucoma, while evidence for severe non‑arteritic anterior ischemic optic neuropathy remains inconclusive.
Probiotic Bifidobacterium pseudocatenulatum converts hesperidin to hesperetin, activating CISD2 and reversing age‑related metabolic decline in mice
Six‑month probiotic‑derived hesperetin treatment reduced body weight and adiposity while improving glucose tolerance, insulin sensitivity, lean mass, and muscle strength in aging mice
EPVS Challenge shows top deep‑learning models reach Dice >0.80 on known sites but lose >20% accuracy on unseen Shanghai cohort
The MedNeXt dual 2D/3D model achieved the highest Dice score, yet its performance declined sharply on the previously unseen Shanghai dataset.
Mild stress triggers hormetic responses that extend Drosophila lifespan and increase survival after heart attack in angina patients
Mild stress was associated with increased survival after heart attack in angina patients.
Intestinimonas remains elevated in aged SAMP8 mice and links to opposite CD4⁺/CD8⁺ T‑cell ratio shifts in brain versus spleen
Aged SAMP8 mice retain higher Intestinimonas levels and show an increased brain CD4⁺/CD8⁺ T‑cell ratio with more pro‑inflammatory CD4⁺ T cells compared to SAMR1 controls.
GLP-1 receptor agonists cut all-cause mortality by 19% in obese patients and slow epigenetic aging clocks
GLP-1 RAs reduced all-cause mortality by 19% (HR 0.81) in obese non-diabetic patients and decelerated DNA methylation aging clocks over 32 weeks of semaglutide therapy.
Molecular hydrogen delivers dual antioxidant and radioprotective actions that may support longevity
Molecular hydrogen reduces oxidative stress and mitigates radiation‑induced cellular damage.