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Human studies reveal limited activation of autophagic flux by fasting and calorie restriction, contrasting robust effects in animal models
Human nutritional interventions (prolonged fasting, intermittent fasting, calorie restriction, macronutrient changes) have shown little or no increase in autophagic flux
Survey Reveals Lifetime Cognitive Enhancer Use Prevalence Among Syrian University Students
The cross‑sectional survey found that a proportion of Syrian university students reported lifetime use of cognitive enhancers (no comparative increase or decrease reported).
Intravenous mitochondria‑rich cytochalasomes cut infarct size by 52% in mouse heart ischemia/reperfusion
A single IV injection of mitochondria‑rich cytochalasomes reduced myocardial infarct size by 52% and preserved cardiac function for up to 28 days in a murine I/R model.
5.4% of centenarians harbor neutralizing type I interferon autoantibodies, indicating prevalence plateaus at extreme age
5.4% of centenarians have neutralizing IFN‑I autoantibodies, showing prevalence levels off compared with individuals aged ≥80 years.
Combined urolithin A and STING inhibitor C176 synergistically reduces liver injury, inflammation, and fibrosis in a mouse steatohepatitis model
In a high‑fat diet/streptozotocin mouse model of steatohepatitis, the combination of urolithin A and C176 produced greater reductions in ALT/AST, lipid accumulation, cGAS‑STING signaling, and fibrosis than either agent alone.
Nutritional cues modulate chaperone-mediated autophagy, altering tumor metabolism and therapeutic response
Nutritional signals such as caloric restriction and fasting regulate CMA, which in turn impacts cancer cell metabolic adaptation and survival
Epitalon upregulates telomere‑maintenance pathways and lowers oxidative‑stress markers but lacks proven clinical efficacy
Epitalon increases telomere‑maintenance activity and reduces oxidative‑stress biomarkers in preclinical models, with no demonstrated therapeutic benefit in human trials.
Body temperature, not hexosamine pathway, controls global protein O-GlcNAcylation across mice, flies, fish and cells
Reduced body temperature lowers global protein O-GlcNAc levels independent of UDP‑GlcNAc availability
fMRI reveals modality-switching bows and a balanced audiovisual axis during natural movie viewing
Large-scale fMRI identified two cortical modality-switching bows and an arrow-like region that jointly encode auditory and visual information in naturalistic comprehension.
Ayurvedic Medhya Rasayanas Upregulate BDNF and Promote Hippocampal Neurogenesis in Models of Cognitive Decline
Ayurvedic herbs such as Bacopa monnieri, Centella asiatica, and Withania somnifera increase BDNF expression and stimulate hippocampal neurogenesis, supporting cognitive resilience.
Chemogenetic modulation of VIP+ neurons in medial prefrontal cortex reduces associative fear learning in mice
Sustained chemogenetic activation or inhibition of VIP+ neurons in the mPFC markedly decreased associative fear learning without affecting anxiety or social behaviors.
Disrupting the Left Inferior Frontal Gyrus Increases Semantic Interference in Picture Naming, Especially for Previously Related Items
Cathodal tDCS over the LIFG slowed naming latencies for items initially presented in related contexts, indicating heightened semantic interference.
Advanced maternal age markedly reduces blastocyst formation and live‑birth rates, linked to distinct age‑associated gene expression and metabolomic shifts in oocytes
Women of advanced age had significantly lower blastocyst formation, pregnancy, and live‑birth rates compared with younger women
Group-living rodents exhibit higher oxytocin and vasopressin puncta in auditory brainstem nuclei
Group-living rodent species have higher oxytocin and vasopressin immunoreactive puncta counts in the lateral superior olive and medial nucleus of the trapezoid body than monogamous and solitary species.
Blood transcriptomic profiling of 2,167 long‑lived individuals uncovers 8,271 age‑associated genes and links higher transcriptomic age to increased mortality
Transcriptomic age derived from blood RNA‑seq rises with chronological age and is strongly associated with higher mortality risk
CA2-3 volume predicts source memory while dentate gyrus volume predicts broader cognitive performance across the adult lifespan
In 163 cognitively healthy adults, larger CA2-3 volume was linked to better source memory and larger dentate gyrus volume was linked to both mnemonic and non‑mnemonic cognitive scores, with effects independent of age
Bacterial extracellular vesicles drive inflammation and insulin resistance in cardiometabolic disease
Bacterial extracellular vesicles increase systemic inflammation and decrease insulin sensitivity, contributing to cardiometabolic disease.